gluten related disorders
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Celiac disease is the core entity in this corpus, but it sits inside a wider borderland of overlapping gluten-triggered or gluten-adjacent conditions.
This page organizes the main neighboring disorders so the knowledge base can distinguish:
- true autoimmune celiac disease
- non-autoimmune symptom syndromes
- extraintestinal gluten-driven manifestations
- lookalikes that change management
The Main Entities
Celiac disease
The central disease in this wiki: autoimmune, HLA-DQ2/DQ8-associated, marked by autoantibodies, villous atrophy, and response to a strict gluten-free diet.
Non-celiac gluten sensitivity
Symptoms triggered by gluten exposure without the defining autoimmune and histological hallmarks of celiac disease.
Wheat allergy
An allergic, typically IgE-mediated response to wheat rather than a T-cell-driven autoimmune enteropathy.
Dermatitis herpetiformis
The skin manifestation of gluten sensitivity; pathognomonic within this disease family.
Gluten ataxia
A neurological manifestation in which gluten-related autoimmunity targets the cerebellar system.
Small intestinal bacterial overgrowth
Not a gluten disorder at all, but a key mimic and one of the most important explanations for persistent symptoms in presumed celiac patients.
High-Level Comparison
| Entity | Immune mode | Villous atrophy | Autoantibodies | Main use in differential |
|---|---|---|---|---|
| Celiac disease | Autoimmune | Yes | Yes | Core diagnosis |
| NCGS | Unclear / heterogeneous | No | No | Borderline symptom syndrome |
| Wheat allergy | Allergic | No | No celiac pattern | Fast allergic differential |
| Dermatitis herpetiformis | Autoimmune / cutaneous | May coexist | IgA tissue deposition | Skin route into diagnosis |
| Gluten ataxia | Autoimmune / neurological | Variable gut involvement | Distinct neural targets | Neurological route into the construct |
| SIBO | Microbial | No | No | Persistent-symptom mimic |
Why This Cluster Matters
This borderland cluster prevents category mistakes:
- not every gluten-responsive patient has celiac disease
- not every persistent symptom on GFD means refractory celiac disease
- some gluten-related disease presents outside the gut first
Organizational Role in the KB
This page acts as a hub between:
Source Basis
Compiled from the current wiki corpus, especially terminology, diagnosis, management, ncgs, dermatitis-herpetiformis, gluten-ataxia, and sibo.